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November 2015

Volume 1 Issue 1


Luteal Phase Progesterone and Four Decades Of In Vitro Fertilization: Many Questions Still Unanswered
Micah J Hill*

The rise of progesterone in natural human reproduction is exquisitely timed to embryo development. The luteinizing hormone surge induces oocyte maturation, ovulation, and progesterone production from the corpus luteum. Progesterone hormone action produces endometrial changes in gene expression, protein production, histologic appearance, and structural arrangements which all lead to an  endometrium receptive for implantation five to six days after ovulation

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Premature Progesterone Rise During in Vitro Fertilization: When to Freeze Embryos and When to Proceed with Embryo Transfer?
Micah J Hill* and George Patounakis

In the natural menstrual cycle, progesterone does not begin to significantly rise until after the LH surge and is therefore precisely timed with ovulation. This leads to synchrony of embryo and endometrial development to facilitate successful embryo implantation. During the ovarian stimulation in in vitro fertilization (IVF) cycles, serum progesterone can be prematurely elevated as a result of the intermediate substrates in the estradiol steroid pathway.  

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A New Window of Opportunity for Improved Diagnosis of Diabetic Polyneuropathy
Dan Ziegler* and Nikolaos Papanas

Diagnosis of diabetic polyneuropathy (DPN), by far the commonest manifestation of diabetes mellitus (DM) in the nervous system, rests on careful clinical examination to reveal length-dependent, symmetrical, primarily sensory deficits in the distal parts of the lower extremities.   

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Lifestyle Modification Program, KOHNODAI Program
Hidekatsu Yanai*, Hisayuki Katsuyama, Akiko Kawaguchi, Sumie Moriyama, Hidetaka Hamasaki, Hiroshi Ohkubo, Keiko Osako, and Airi Sanada

Obesity is known to be associated with metabolic disorders, such as glucose intolerance, hypertension and dyslipidemia. Especially, metabolic abnormalities in obesity have been shown to be frequently associated with abdominal obesity.    

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Nutritional Therapy and Glycemic Variability among People with Diabetes
Refaat A Hegazi*, Rachel A Johnson, Amy A Devitt

Glycemic variability (GV) represents the acute fluctuation of blood glucose levels from peak to nadir. Over the last decade, GV has increasingly become part of the dialogue surrounding glycemic control, as evidenced by the growingnumber of articles published on this topic over the past few years. 


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Case Report

Development of Thyroid-Stimulating Antibodies and Thyrotoxicosis in a Case of Advanced Follicular Thyroid Carcinoma
Shoko Natsuda, Ichiro Horie, Takao Ando*, Atsushi Kawakami

It is extremely rare that thyroid cancer produces enough thyroid hormone to cause thyrotoxicosis. We report the case of a 69-year-old Japanese female who developed thyrotoxicosis associated with advanced follicular thyroid carcinoma. The patient had been under levothyroxine replacement therapy for 10 years after a total thyroidectomy, and had undergone radioiodine therapy three times because of multiple lung and bone metastases.


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Research Article

Leptin Resistance and Insulin Resistance Go Hand In Hand, but Lipids are Left Behind
Djordje S. Popovic, MD*, Dragana Tomic-Naglic, MD, PhD, Milena Mitrovic, MD, PhD, Tijana Icin, MD, PhD, Ivana Bajkin, MD, Biljana Srdic-Galic, MD, PhD, Jovanka Novakovic-Paro, MD, PhD, Maja Ruzic, MD, PhD, Bojan Vukovic, MD, Edita Stokic, MD, PhD

Leptin is a hormone secreted by adipose tissue in direct proportion to amount of body fat and it regulates energy homeostasis. Leptin resistance is often associated with insulin resistance and lipid metabolism disorders in obese persons. Study investigates correlation of leptinemia with insulin resistance, and lipid and lipoprotein metabolism parameters in obesity. Study included 60 obese patients. The most common endocrine causes of obesity (hypothyroidism, hyperprolactinemia, hypercortisolism and insulinoma) were eliminated. 

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Original Research

MCPIP1 Deficiency Increases Insulin Sensitivity But Impairs Hepatic Insulin Signal Transduction in Mice
Brett B. Holdaway, Joshua D. Moody, Lauren F. Brooks, Mingui Fu, Pappachan Kolattukudy, and Yingzi Chang*

Chronic inflammation is associated with pathogenesis of metabolic disorders, including insulin resistance. MCPIP1 (monocyte chemotactic protein [MCP]–induced protein 1; also known as ZC3H12A) is a newly discovered RNase that is essential in controlling inflammatory response and immune homeostasis. Our current study was designed to test if MCPIP1 deficiency affects glucose homeostasis by regulating the insulin signal transduction pathway in liver and/or adipose tissue, the two major organs that are involved in maintaining glucose homeostasis.

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Inrerventional Study

Continuous Glucose Monitoring Assessment of Glucose Variability with Liraglutide add-on or Substitution in T2DM during 24 hour and 3 hour
Paul M. Rosman, DO, Jeffrey S. Freeman*, DO, Jayme A. Aschemeyer, DO, David M. Capuzzi, MD, PHD

Medication add-ons and substitutions used commonly to improve glucose management in people with diabetes may create unforeseen interactions that complicate patient care. We addressed this concern using Continuous Glucose Monitoring (CGM) from which we measured glycemic variability as a metric of successful add-on or substitution. Additionally, we compared calculated HbA1c differences between pre liraglutide and post liraglutide treatment mean 24 hour studies. Lastly, we looked at hypoglycemic predictability as a tool to evaluate patient safety when add-ons or substitutions occur.

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Original Article

Effects of Lifestyle Modification Program, KOHNODAI Program, on Metabolic Parameters in Japanese Obese People
Akiko Kawaguchi, MD, Hisayuki Katsuyama, MD, PhD, Hidekatsu Yanai, MD, PhD*

We developed the program to support obese patients to change their lifestyle related with obesity, KOHNODAI program. Here we studied effects of KOHNODAI program on metabolic parameters in 19 Japanese obese people. Mean body weight significantly decreased to 79.9 kg immediately after the KOHNODAI program, and at 3 (79.7 kg) and 6 months (77.3 kg) after the program as compared with body weight before the program (81.7 kg). Serum high-density lipoprotein-cholesterol levels significantly increased, and alanine aminotransferase tended to decrease 6 months after the program.

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