Volume 3 Issue 1
Energy Regulating Hormones Correlate with Erythrocyte MicroRNA Expression in Type 2 Diabetic African-American Adults
Maurice B. Fluitt, Namita Kumari, Gail Nunlee-Bland, Sergei Nekhai, Kanwal K. Gambhir*
This study aimed to identify the relationships between type 2 diabetes mellitus (T2DM) related miRNAs in erythrocytes and energy regulating hormones in pre-diabetic and obese type 2 diabetic African-American adults. Patients were recruited from the Howard University Hospital Diabetes Treatment Center. The expression of nine previously reported T2DM-related miRNAs was quantified using qRT-PCR. Radioimmunoassays were employed to determine plasma hormone concentrations of total ghrelin, leptin, vitamin D (25(OH)D) and C-peptide. Pearson’s correlation was performed to identify significant relationships between erythrocyte miRNAs and hormone concentration.